MovDisordV3, Main, Exploration, bibRecord, 004B53

Allelic association between the DRD2 TaqI A polymorphism and Parkinson's disease

Identifieur interne : 004B53 ( Main/Exploration ); précédent : 004B52; suivant : 004B54

Allelic association between the DRD2 TaqI A polymorphism and Parkinson's disease

Auteurs : L. Grevle [Norvège] ; C. Güzey [Norvège] ; H. Hadidi [Norvège] ; R. Brennersted [Norvège] ; J. R. Idle [Norvège] ; J. Aasly [Norvège]

Source :

Movement Disorders [ 0885-3185 ] ; 2000-11.

RBID : ISTEX:88ECCB66FB23ECD13DCA1C1D892EE1E4431C7350

Descripteurs français

Pascal (Inist)
- Allèle, Déterminisme génétique, Facteur risque, Gène, Génotype, Homme, Parkinson maladie, Polymorphisme, Réaction chaîne polymérase, Récepteur dopaminergique D2.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Allele, Alleles, Case-Control Studies, Chi-Square Distribution, Chromosomes, Human, Pair 11 (genetics), D2 Dopamine receptor, D2 receptor, Female, Gene, Gene polymorphism, Genetic determinism, Genotype, Human, Humans, Male, Middle Aged, Odds Ratio, Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Polymerase chain reaction, Polymorphism, Polymorphism, Restriction Fragment Length, Receptors, Dopamine D2 (genetics), Risk factor.
MESH :
- chemical , genetics : Receptors, Dopamine D2.
- genetics : Chromosomes, Human, Pair 11, Parkinson Disease.
- Aged, Aged, 80 and over, Alleles, Case-Control Studies, Chi-Square Distribution, Female, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Restriction Fragment Length.

Abstract

Genes encoding proteins involved in dopaminergic transmission have been of special interest during the evaluation of candidate genes for Parkinson's disease (PD). The dopamine D2 receptor gene (DRD2) is located on chromosome 11 q22‐q23, and several polymorphisms of the gene have been described. The DRD2 gene has a TaqI A restriction fragment length polymorphism that is located in the untranslated region, approximately 10 kilobases from the 3′ end of the gene. This polymorphism creates the two alleles A1 (variant) and A2. In this study, we investigated the hypothesis that a TaqI repeat fragment length polymorphism in the dopamine D2 receptor gene may be associated with PD. DNA from 72 patients with PD, classified as definite, probable, or atypical PD, and from 81 controls was genotyped by polymerase chain reaction and gel electrophoresis for the presence of the TaqI A1 polymorphism. The controls were matched for age, race, and geographic origin. There were significant differences in allelic distribution between the overall PD group and control groups (χ2 = 5.009, p = 0.025). When only patients with definite PD were considered an even more significant association was found (χ2 = 8.2121, p = 0.004). Among the overall PD group, the odds ratio for having the variant allele A1 was found to be 2.2 (95% confidence interval, [1.1; 4.4]), whereas it was calculated to be 3.0 (95% confidence interval, [1.4; 6.4]) when only patients with definite PD were considered. The current study showed that there is a statistically significant association between the DRD2 variant allele A1 and PD. This association is most pronounced in patients with definite PD and becomes nonsignificant when the clinical picture is classified as atypical PD.

Url:

https://api.istex.fr/document/88ECCB66FB23ECD13DCA1C1D892EE1E4431C7350/fulltext/pdf

DOI: 10.1002/1531-8257(200011)15:6<1070::AID-MDS1003>3.0.CO;2-A

Affiliations:

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<front><div type="abstract" xml:lang="en">Genes encoding proteins involved in dopaminergic transmission have been of special interest during the evaluation of candidate genes for Parkinson's disease (PD). The dopamine D2 receptor gene (DRD2) is located on chromosome 11 q22‐q23, and several polymorphisms of the gene have been described. The DRD2 gene has a TaqI A restriction fragment length polymorphism that is located in the untranslated region, approximately 10 kilobases from the 3′ end of the gene. This polymorphism creates the two alleles A1 (variant) and A2. In this study, we investigated the hypothesis that a TaqI repeat fragment length polymorphism in the dopamine D2 receptor gene may be associated with PD. DNA from 72 patients with PD, classified as definite, probable, or atypical PD, and from 81 controls was genotyped by polymerase chain reaction and gel electrophoresis for the presence of the TaqI A1 polymorphism. The controls were matched for age, race, and geographic origin. There were significant differences in allelic distribution between the overall PD group and control groups (χ2 = 5.009, p = 0.025). When only patients with definite PD were considered an even more significant association was found (χ2 = 8.2121, p = 0.004). Among the overall PD group, the odds ratio for having the variant allele A1 was found to be 2.2 (95% confidence interval, [1.1; 4.4]), whereas it was calculated to be 3.0 (95% confidence interval, [1.4; 6.4]) when only patients with definite PD were considered. The current study showed that there is a statistically significant association between the DRD2 variant allele A1 and PD. This association is most pronounced in patients with definite PD and becomes nonsignificant when the clinical picture is classified as atypical PD.</div>
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Movement Disorders (revue)

Allelic association between the DRD2 TaqI A polymorphism and Parkinson's disease

Allelic association between the DRD2 TaqI A polymorphism and Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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